时间：2024年11月13日（周一）上午 10:00~11:30

Time：10:00~11:30AM, Wednesday, Nov.13th, 2024

地点：西湖大学云谷校区E10-201阶梯教室

Venue: E10-201, Yungu Campus

主持人：西湖大学生命科学学院 助理教授党波波

Host: Assistant Professor Bobo Dang,School of Life Sciences

主讲人/Speaker：

William (Bill)  DeGrado 

Department of Pharmaceutical Chemistry

University of California

William (Bill) DeGrado’s work focuses on the design of small molecule drugs, peptides, and proteins to address biological and mechanistic questions. Since 2011, Bill has been a professor in the Department of Pharmaceutical Chemistry at the University of California San Francisco. Prior to UCSF, he worked in both academics and industry, including the Raiziss Professor in the Department of Biochemistry and Biophysics at the University of Pennsylvania (1996 – 2011); DuPont Merck Pharmaceutical Company (1990 – 1996); DuPont Central Research (1981 to 1990). He graduated from Kalamazoo College in 1978, received his Ph.D. in organic chemistry from the University of Chicago (1981), and joined DuPont Central Research without an intervening postdoctoral position. He is an elected member of the National Academy of Sciences (1999), the American Academy of Arts and Sciences (1998), and the National Academy of Inventors (2014).

报告题目/Title:

De Novo Protein Design of Functional Proteins

讲座摘要/Abstract:

Not too long ago, the design of proteins from scratch that fold into predictable structures was considered an impossible task, but with advances in machine learning and artificial intelligence it is now increasingly routine.  Given our ability to design protein structures the next challenge has been to design function.  The success or failures of the designs informs our understanding of the principles underlying the desired function and additionally provides the first step towards the design of proteins with useful functions not found in natural proteins.  This talk will describe the design of proteins for the recognition and delivery of small molecule drugs, nucleotide sequencing, and environmentally friendly catalytic processes.

讲座联系人/Contact:

科技合作部 Sci-tech02@westlake.edu.cn