PUBLICATIONS
*Co-first author, #Corresponding author.（Update Date：2024-5-6）
2024
Zheng Y*,Yang Q*,Luo J,Zhang Y,Li X,He L,Ma C,Tao L#(2024) Identification of a hemorrhagic determinant inP. sordelliiTcsH andC. difficileTcdA.Microbiology Spectrum12(6), e0035424[Full Text]
Zhou R*,He L*,Zhang J*, Zhang X, Li Y,Zhan X#,Tao L#(2024) Molecular basis of TMPRSS2 recognition byPaeniclostridium sordelliihemorrhagic toxin.Nature Communications15: 1976[Full Text]
Zeng J#, Fang S, Guo J, Dong M, Tian G#,Tao L#(2024) Fight or flee, a vital choice forClostridioides difficile.mLife3(1): 14-20[Full Text]
2023
Zhou Y*, Zhan X*#,Luo J,Li D, Zhou R,Zhang J,Pan Z,Zhang Y,Jia T, Zhang X, Li Y,Tao L#(2023) Structural dynamics of CROPs control stability and toxicity ofPaeniclostridium sordelliilethal toxin.Nature Communications14: 8426[Full Text]
He A, Tian S, Kopper O, Horan D, Chen P, Bronson R, Sheng R, Wu H, Sui L, Zhou K,Tao L, Wu Q, Huang Y, Shen Z, Chen H, He X, Robling A, Jin R, Clever H, Xiang D#, Li Z#, Dong M#(2023) Targeted inhibition of Wnt signaling with aClostridioides difficilefragment suppresses breast cancer tumor growth.PLOS Biology21(11), e3002353[Full Text]
Hou Y, Xie T,He L,Tao L, Huang J (2023) Topological links in predicted protein complex structures reveal limitations in AlphaFold.Communications Biology6: 1098[Full Text]
2022
Hui Y*#, Yao Y*, Qian Q,Luo J, Chen H, Qiao Z, Yu Y,Tao L#, Zhou N#(2022) Three-dimensional printing of soft hydrogel electronics.Nature Electronics5, 893-903[Full Text]
Li D*,Zhou Y*,Tao L#(2022) Intestinal mucosa barrier and pathogenic bacterial infection.Progress in Physiological Sciences53(6): 416-421
Liang G*, Lai C*, Yue Z, Zhang H,Li D, Chen Z, Lu X,Tao L, Subach F, Piatkevich K# (2022) Enhanced small green fluorescent proteins as a multi-sensing platform for biosensor development.Frontiers in Bioengineering and Biotechnology10: 1039317.[Full Text]
Zhou Y*,Li D*,Li D,Chen A,He L,Luo J,Tao L#. (2022) LDLR, LRP1, and Megalin redundantly participate in the uptake ofClostridium novyialpha-toxin.Communications Biology5: 906.[Full Text]
Yang Q,Zhou Y,He L,Zhang Y, andTao L#(2022) Protocol for genome-wide CRISPR knockout screens of bacterial cytotoxins in HeLa cells.STAR Protocols3:101595.[Full Text]
Li X*,He L*,Luo J,Zheng Y,Zhou Y,Li D,Zhang Y,Pan Z, Li Y,Tao L#(2022)Paeniclostridium sordelliihemorrhagic toxin targets TMPRSS2 to induce colonic epithelial lesions.Nature Communications13:4331.[Full Text]
He L*, Huang X*, Zhang G, Yuan L,Shen E, Zhang L, Zhang X-H, Zhang T,Tao L#,Ju F# (2022) Distinctive signatures of pathogenic and antibiotic-resistant potentials in the hadal microbiome.Environmental Microbiome17:19.[Full Text]
Luo J*,Yang Q*, Zhang X*,Zhang Y*, Wan L*, Zhan X,Zhou Y,He L,Li D, Jin D, Zhen Y, Huang J, Li Y#,Tao L#(2022) TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2C. difficile.Cell185(6): 980-994. [Full Text]
Wang L*,Li D*, Chen Z,He L, Wang X#,Tao L#(2022) An atypical case of monomicrobialClostridioides difficilesepticemia with no gastrointestinal manifestations.Frontiers in Cellular and Infection Microbiology12:35.[Full Text]
2021
Zhou Y*,Li D*,Luo J*,Chen A,Li X,Pan Z,Wan L,He L,Li D, Li Y, Dong M,Tao L#(2021) Sulfated glycosaminoglycans and low-density lipoprotein receptor mediate the cellular entry ofClostridium novyialpha-toxin.Cell Research31(8):935-938[Full Text]
Chen P*, Zeng J*, Liu Z, Thaker H, Wang S, Tian S, Zhang J,Tao L, Gutierrez C, Xing L, Gerhard R, Huang L, Dong M#, Jin R# (2021) Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target inClostridioides difficileinfection.Nature Communications12, 3748.[Full Text]
Pan Z*,Zhang Y*,Luo J*,Li D,Zhou Y,He L,Yang Q, Dong M#,Tao L#. (2021) Functional analyses of epidemicClostridioides difficiletoxin B variants reveal their divergence in utilizing receptors and inducing pathology.PLoS Pathogens17(1):e1009197.[Full Text]
2020
Henkel D, Tatge H, Schottelndreider D,Tao L, Dong M, Gerhard R.(2020) Receptor binding domains of TcdB fromClostridioides difficilefor chondroitin sulfate proteoglycan-4 and Frizzled proteins are functionally independent and additive.Toxins12(12):736.[Full Text]
Shen E, Zhu K,Li D,Pan Z,Luo Y, Bian Q,He L, Song X, Zhen Y, Jin D,Tao L#. (2020) Subtyping analysis reveals new variants and accelerated evolution ofClostridioides difficiletoxin B.Communications Biology3(1):347.[Full Text]
2019
Tao L*#,Tian S*, Zhang J*, Liu Z, Robinson-McCarthy L, Miyashita SI, Breault DT, Gerhard R, Oottamasathien S, Whelan SPJ, Dong M#. (2019) Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute toClostridium difficiletoxin A entry into cells.Nature Microbiology4,1760–1769.[Full Text]
Chen P,Tao L, Liu Z, Dong M, Jin R. (2019) Structural insight into Wnt signaling inhibition byClostridium difficiletoxin B.FEBS Journal286, 874-881.[Full Text]
Before 2019
Chen P*,Tao L*, Wang T, Zhang J, He A, Lam K, Liu Z, He X, Perry K, Dong M, Jin R. (2018) Structural basis for recognition of frizzled proteins byClostridium difficiletoxin B.Science360: 664-669.[Full Text]
Tian S, Muneeruddin K, Choi MY,Tao L, Bhuiyan RH, Ohmi Y, Furukawa K, Boland S, Shaffer SA, Adam RM, Dong M.(2018) Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation.PLoS Biology16, e2006951.[Full Text]
Zhang S, Lebreton F, Mansfield M.J., Miyashita SI, Zhang J, Schwartzman JA,Tao L, Masuyer G, Martı´nez-Carranza M, Stenmark P, Gilmore MS, Doxey AC, Dong M. (2018) Identification of a botulinum neurotoxin-like toxin in a commensal strain ofEnterococcus faecium.Cell Host & Microbe23:169-176.[Full Text]
Tao L*, Peng L*, Berntsson RP-A, Park S, Yu F, Boone C, Stenmark P, Krupp J, Dong M. (2017) Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors.Nature Communications8, 53.[Full Text]
Zhang S, Berntsson RP-A, Tepp W,Tao L, Johnson E, Stenmark P, Dong M.(2017) Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC.Nature Communications8, 1637.[Full Text]
Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup BW, Miao J, He X, Hurdle GJ, Breault TD, Brass AL, Dong M. (2016) Frizzled proteins are colonic epithelial receptors forC. difficiletoxin B.Nature538:350-355.[Full Text]
Jana B,Tao L, Biswas I. (2016) Strain-Dependent Recognition of a Unique Degradation Motif by ClpXP inStreptococcus mutans.MSphere1(6), e00287-16.[Full Text]
Tao L, Biswas I. (2015) Degradation of SsrA-tagged proteins in streptococci.Microbiology161:884-894.[Full Text]
Peng L, Adler M, Demogines A, Borrell A, Liu H,Tao L, Tepp WH, Zhang SC, Johnson EA, Sawyer SL, Dong M. (2014) Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins.PLoS Pathogens10: e1004177.[Full Text]
Tao L,Biswas I. (2013) ClpL is required for folding of CtsR inStreptococcusmutans.Journal of Bacteriology195: 576-584.[Publisher Link]
Tao L, Chattoraj P, Biswas I. (2012) CtsR regulation in mcsAB deficient gram-positive bacteria.Journal of Bacteriology194:1361-1368.[Publisher Link]
Wu X, Wang Y,Tao L#. (2011) Sulfhydryl compounds reduceStaphylococcusaureusbiofilm formation by inhibiting PIA biosynthesis.FEMS Microbiology Letters316: 44-50.[Publisher Link]
Tao L*, Wu X*, Sun B. (2010) Alternative sigma factor σHmodulates prophage integration and excision inStaphylococcusaureus.PLoS Pathogens6(5): e1000888.[Publisher Link]