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Westlake Gut Project (WeGut)

·The interplay among diet, lifestyle factors, host genetics and the gut microbiome in human health.
·The role of the gut microbiome for the precision prevention of chronic diseases in Chinese populations.
    Abstract figure of WeGut Program

    The WeGut project aims to provide a platform for the integration of gut microbiome data across different cohort studies, including two major components:

    1) cohorts for healthy ageing.

    2) cohorts for healthy pregnancy.

    The WeGut consortium includes seven core/foundation cohorts involvingover 32,000 participantswith gut microbiome and rich phenotype data across17 provinces/megacitiesin China. Within the WeGut framework, we hope to disentangle the interplay among diet, lifestyle factors, host genetics and the gut microbiome in human health and explore the role of the gut microbiome for the precision prevention of chronic diseases in Chinese populations.

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Cohorts for Healthy Ageing

Cohort 1:
China Health and Nutrition Survey (CHNS)

The CHNS is a national and longitudinal prospective study, which were completed around every 3 years from 1989 to 2018.

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Cohort 2:
Guangdong Gut Microbiome Project (GGMP)

The GGMP was a cross-sectional study with 7,009 participants aged 18 to 97 years enrolled from 14 districts within Guangdong Province, China.

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Cohort 3:
Guangzhou Nutrition and Health Study (GNHS)

The GNHS is a prospective study involved 4,048 participants from 2008 to 2013 in Guangzhou, China. Participants were followed up every 3 years for the collection of phenotype measurements and biological samples.

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Cohort 4:
Zhejiang Metabolic Syndrome Cohort (ZMSC)

The ZMSC is a longitudinal study that started from 2010 to 2014 as a baseline, and enrolled the residents from Putuo district in Zhoushan islands and Xiaoshan, Zhejiang, China.

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Cohorts for Healthy Pregnancy

Cohort 1:
Tongji-Shuangliu Birth Cohort (TSBC)

The TSBC is an ongoing birth cohort in Chengdu, China, and was designed to enrol early pregnant women aged 18 to 40 years.

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Cohort 2:
Westlake Precision Birth Cohort (WeBirth)

The Westlake Precision Birth Cohort (WeBirth) is a prospective birth cohort study based on pregnant women with gestational diabetes mellitus (GDM) and their offspring. The WeBirth aims to investigate precision nutrition for GDM patients (n~2000) by incorporating standardized meal tests and continuous glucose monitoring to test their personalized glucose response to diet.

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Dietary Intervention

·Precision Nutrition.
·N-of-1 study design.
Study 1:
Westlake N-of-1 Trials for Macronutrient Intake Study
(WE-MACNUTR)

WE-MACNUTR is a dietary intervention study, the first application of N-of-1 methods in advance personalized nutrition.

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Study 2:
Westlake Precision Nutrition Study (WePrecision)

WePrecision is a dietary intervention study intergrated with concepts of precision nutrition and N-of-1 study design, which aims to explore different diet challenges for glucose metabolism.

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Other Cohorts

Cohort 1:
Westlake Personalized Nutrition and Health Cohort for
Drug Addicts (WePN-DA)

WePN-DA is a prospective cohort study of drug addicts in Zhejiang. The primary aim is to investigate the association between diet and health status among drug addicts.

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Cohort 2:
Jiaxing Birth Cohorts

Jiaxing Birth Cohort is an unique resource to explore prenatal risk factors, early life feeding practice and growth pattern/adiposity in Chinese children. .

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